Chlorop Eye Ointment Mechanism of Action

Pharmacology: Pharmacodynamics: Mode or Mechanisms of Action: Bacteriostatic, since it is lipid-soluble, it diffuses through the bacterial cell membrane and reversibly binds to the 50 S subunit of bacterial ribosomes where transfer of amino acids to growing peptide chains is prevented (perhaps by suppression of peptidyl transferase activity), thus inhibiting peptide bond formation and subsequent protein synthesis.
The actions of Chloramphenicol affect many types of bacteria. Gram-positive cocci include staphylococci, streptococci, enterococci, Bacillus anthracis, Corynebacterium diphtheriae, and anaerobes. Gram-negative cocci include Neisseria meningitidis and N. gonorrhoeae, Haemophilus influenza and other gram-negative species such as Brucella bortus, Campylobacter, Legionella pneumophila, Pasteurella, Vibrio and Yersinia.
Chloramphenicol is active against the following common bacterial eye pathogens: Staphylococcus aureus; Streptococci, including Streptococcus pneumoniae; Escherichia coli; Haemophilus influenzae; Klebsiella/Enterobacter species; Moraxella lacunata (Morax-Axenfeld bacillus); Neisseria species.
This product does not provide adequate coverage against: Pseudomonas aeruginosa, Serratia marcescens.
Pharmacokinetics: Absorption: Intraocular and some systemic absorption occur following topical application to the eye.
Distribution: Aqueous humour- Measurable concentration following topical application to the eye.